What are the side effects of indomethacin that healthcare providers should monitor for?

Indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), is often used in neonatal care, particularly for conditions such as patent ductus arteriosus (PDA) in premature infants. It is critical for healthcare providers to monitor specific side effects that can arise from its use.

The correct side effects to monitor include hyponatremia and inhibition of platelet aggregation. Hyponatremia, a decrease in sodium levels, can occur as a result of indomethacin's effect on renal function and fluid balance, potentially leading to serious complications if not addressed. Inhibition of platelet aggregation is a significant concern as indomethacin can interfere with the normal functioning of platelets, which may increase the risk of bleeding, especially crucial in a vulnerable neonatal population.

Monitoring these side effects is essential for ensuring the safety and well-being of infants receiving this treatment, as both hyponatremia and effects on platelet function can have immediate clinical implications. Understanding how indomethacin affects sodium balance and platelet aggregation allows for better management and adjustment of treatment to minimize risks associated with these side effects.