What is often associated with omphalocele in newborns?

The association of omphalocele with Beckwith-Wiedemann syndrome is well-documented. Beckwith-Wiedemann syndrome is a genetic disorder characterized by overgrowth and specific anatomical features, including omphalocele, macroglossia, and abdominal wall defects. The presence of omphalocele in infants with this syndrome is significant, as it indicates a failure of the abdominal contents to return to the abdominal cavity during fetal development.

This association is important because it highlights the need for careful monitoring and management of infants with omphalocele, particularly considering the potential for underlying syndromic conditions. While omphalocele can occur with other anomalies and syndromes, Beckwith-Wiedemann stands out due to its specific and often recurrent manifestation alongside this defect, influencing the approach to care and potential genetic counseling for families.