What is the result of increased 2,3 DPG in the blood?

Increased levels of 2,3-Diphosphoglycerate (2,3-DPG) in the blood facilitate a rightward shift of the oxygen-hemoglobin dissociation curve. This shift decreases hemoglobin's affinity for oxygen, making it more readily available to tissues that require it. As a result, even if the saturation of hemoglobin with oxygen may decrease, the primary effect of elevated 2,3-DPG is enhanced oxygen delivery to tissues.

This mechanism is particularly important in conditions where oxygen delivery needs to be increased, such as during hypoxia, anemia, or even in states of increased metabolic demand. Tissues needing more oxygen will benefit from this shift, allowing them to extract oxygen more efficiently from hemoglobin.

The overall effect of increased 2,3-DPG is, therefore, improved oxygen delivery to tissues, which supports cellular metabolism and function.