What percentage of children with congenital heart disease (CHD) is attributed to multifactorial inheritance?

Multifactorial inheritance plays a significant role in congenital heart disease (CHD), with a large percentage attributed to both genetic and environmental factors. Research indicates that approximately 70-85% of cases of CHD are linked to multifactorial causes. This can encompass a combination of genetics, maternal health, teratogenic exposures, and other environmental aspects that interact in complex ways leading to the development of heart defects. Understanding this high percentage highlights the importance of looking at CHD not just through a strictly genetic lens, but also considering how various factors may contribute to its occurrence. This knowledge is crucial for healthcare professionals in their approach to prevention, early detection, and management of CHD in affected infants.