Which medication is commonly used to treat systemic candidiasis in neonates?

Fluconazole is commonly used to treat systemic candidiasis in neonates because it is effective against various strains of Candida and is well-tolerated. This antifungal medication is advantageous for neonates due to its ability to penetrate the central nervous system, making it suitable for treating invasive candidiasis that can affect the brain and other critical areas in this vulnerable population.

Amphotericin B, although a potent antifungal also indicated for severe systemic infections, is associated with significant side effects, such as nephrotoxicity, which makes it less desirable as a first-line treatment in neonates. Nystatin is primarily used for oral and cutaneous candidiasis and does not effectively treat systemic infections. Gentamicin, on the other hand, is an antibiotic used for bacterial infections and has no antifungal properties, making it irrelevant for the treatment of candidiasis.