Which of the following drugs is known to negatively affect neonatal renal function?

All of the listed drugs are known to have potential negative effects on neonatal renal function. Furosemide, a loop diuretic, can lead to diuresis, which may result in dehydration and electrolyte imbalances, adversely affecting renal perfusion and function in a vulnerable neonatal population. Dopamine, often used for its cardiovascular effects, can, in some cases, lead to renal vasoconstriction, particularly at higher doses, which could compromise kidney function. Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), may also have renal implications, as it can lead to decreased renal blood flow, especially in preterm infants where renal function is still maturing.

Understanding the effects of these medications is crucial in neonatal intensive care, where the structure and function of the kidneys are not fully developed, making neonates particularly susceptible to renal injury from pharmacological interventions. Therefore, considering the potential impact of each drug, it is accurate to state that all of these drugs can negatively affect renal function in neonates.