Which of the following is a common risk factor for omphalocele?

Omphalocele is a congenital defect characterized by the protrusion of abdominal contents through the abdominal wall at the umbilical site, covered by a thin membrane. The correct answer identifies malrotation as a common risk factor associated with this condition. Malrotation refers to an abnormal rotation of the intestines during fetal development, which can be part of a spectrum of developmental defects, including omphalocele.

The association between malrotation and omphalocele arises because both involve disruptions in the normal development of the gastrointestinal tract. Factors affecting abdominal wall formation and positioning during fetal development may result in both congenital anomalies. Understanding these developmental processes highlights why malrotation is a significant risk factor.

While maternal smoking, advanced paternal age, and increased maternal weight have been scrutinized in various studies regarding congenital anomalies, they are not specifically linked as risk factors for omphalocele compared to malrotation. Thus, recognizing malrotation's role in the development of omphalocele provides clearer insight into the etiology of this congenital condition and its associated risks.