Which organism is most commonly associated with candidiasis in neonates?

Candida albicans is the organism most commonly associated with candidiasis in neonates. This yeast is part of the normal flora of the human body but can become pathogenic, particularly in vulnerable populations such as newborns, especially those in the neonatal intensive care unit (NICU). Neonates, particularly those with low birth weight, are at increased risk because of their immature immune systems and the potential for invasive procedures, such as central venous catheter placements, which can introduce the organism into the bloodstream.

Candidiasis can manifest in various forms, including oral thrush and invasive candidiasis, which can lead to serious complications if not treated promptly. The predisposition of neonates to candidiasis underscores the importance of close monitoring for signs of infection and appropriate antifungal treatment in high-risk infants.

The other organisms listed, such as Aspergillus fumigatus, Staphylococcus epidermidis, and Pseudomonas aeruginosa, do have clinical significance, but they are not the primary organisms responsible for candidiasis in neonates. Aspergillus species are typically associated with mold infections and can affect immunocompromised patients. Staphylococcus epidermidis is largely considered a skin flora organism that can lead to infections, particularly in the setting of medical devices